
Based on the provided information, yes, Rena Sofer is leaving her role as Lois Cerullo on General Hospital in 2025.
According to reports from August 2025, the actress announced she is moving out of Los Angeles after living and working there for nearly 35 years. Sofer and her husband are relocating to New York state in pursuit of "quieter and calmer times."
While her departure from the show and Hollywood is confirmed, one source indicates that she has also talked about a potential return in the future. However, the immediate news is that she is exiting the series.


