Summary: Participate in a clinical study exploring dihydroberberine's metabolic impact on energy, mood, and appetite. Highlights: 1. Explore the total-body metabolic impact of dihydroberberine 2. Contribute to understanding appetite-regulating hormones and insulin sensitivity 3. Engage in a lifestyle intervention program promoting weight loss It's Not Just Weight. It's Energy, Mood, and Appetite. Enroll in our study to explore dihydroberberine's total-body metabolic impact. Complete 3 visits and you could receive a FitBit activity tracker, smart scale, and earn up to $600. Recent clinical studies suggest that a supplement called berberine may impact appetite-regulating hormones like glucagon-like peptide-1 (GLP-1); insulin sensitivity (how your body responds to the insulin in your blood); blood glucose levels and weight loss. Dihydroberberine (DHB), is a form of berberine that has the same characteristics but may be better absorbed by the body. The total study participation is approximately 14 weeks with 3 in-clinic visits. Two of the visits require you to be at the clinic for a 3.5-hour period. During these visits you will have an IV catheter inserted in your arm for multiple blood draws. At Visit 2, you’ll be educated on a lifestyle intervention program that promotes weight loss through caloric restriction and physical activity. Throughout the study, you will record your weight at home, weekly. If qualified, you may be compensated up to $600 for completing all study visits and tasks, in addition to receiving a physical activity tracker and digital scale. Qualified participants must: -Be an adult between 35-65 years of age -Have a BMI ≥ 27 and ≤ 39.9 kg/m2 -Consume 4 capsules a day for 12 weeks -Complete 2 DXA body scans and 2 3D body scans to assess body composition -Wear a physical activity tracker and weigh yourself at-home weekly -Complete weekly mood, appetite, and energy questionnaires -Download a smart phone application to track weight, physical activity, and food and beverage intake Click the link to see if you qualify - https://biofortis.clinicalconductor.com/CCSWEB/Forms/frmSurveyPreview.aspx?Direct=1&Mode=0&SurveyPKey=255&StudyPKey=6755