United States Biotechnology & Genetics Job Listings

Preventive Medicine

Gene Editing Scientist

South San Francisco, CA, USA

Preventive Medicine is a venture‑backed biotech startup developing next‑generation reproductive‑genetics platforms to eliminate severe genetic disease before birth. As one of the first scientific hires, you will help define our technical roadmap, build our R&D culture from the ground up, and influence the long‑term direction of the company. We are seeking an entrepreneurial Scientist to design, build, and evaluate advanced adenine & cytosine base editors (ABE, CBE) and RT editors. Partnering directly with the co‑founders, you will take new editor concepts from the bench to IND‑enabling studies while laying the foundation of our research organization. Key Responsibilities Establish the editor‑engineering pipeline – Optimize ABE/CBE/RT‑editing architectures for potency, specificity, and manufacturability High‑throughput cloning & screening workflows (automated assembly, pooled libraries, functional reporters) and streamline data capture Develop quantitative assays for on‑ and off‑target analysis using cutting‑edge sequencing and bioinformatics platforms. Drive preclinical translation in relevant cell models and preclinical species Recruit, mentor, and lead a small team of research associates and scientists; Communicate program progress through protocols, data packages, and presentations to investors, advisors, and regulatory consultants. Requirements Minimum Qualifications 5+ years hands‑on experience engineering CRISPR base or prime editors in mammalian systems – demonstrated impact matters more than formal credentials. Proficiency with NGS library preparation & analysis (e.g., CRISPResso2, CRISPR‑RGEN Tools) and basic Python/R scripting for data processing. Proven track record of leading complex projects and publishing or patenting influential work. Strong work ethic, scientific rigor, and high integrity. Preferred qualifications Familiarity with regulatory standards and assays relevant to gene‑editing therapeutics Experience generating and using RNPs and mRNA for gene editing, including delivery via electroporation or nanoparticles. Prior startup or small‑team experience in fast‑moving environments. Comfort with automation (liquid handlers, LIMS) and/or single‑cell genotyping/transcriptomics. Benefits Competitive salary plus meaningful equity—share in the company’s upside. Comprehensive health, dental, and vision coverage. 401(k) with company match.

Negotiable Salary