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PURPOSE OF STUDY: Alastin Skincare is conducting a 14-Week research study to evaluate the effects of an investigational topical body lotion for improving body skin quality. The study Test Product may improve the appearance of your skin but cannot be guaranteed. Study participants will apply the study Test Product twice daily ONLY to the assigned body areas (1 knee & 1 upper inner arm) and use an approved body cleanser and sunscreen for the duration of the study. No products will be used on the untreated side (knee & upper inner arm). To be considered for study participation, you must: • Be a healthy female or male ages 40 to 75 years. • Have Moderate to Severe crepey (crinkly) skin of the upper inner arms & knees. • Have Mild to Severe laxity (loose) skin of the upper inner arms & knees. • Have Mild to Severe skin roughness & dryness of the upper inner arms & knees. • Be willing to use ONLY the study provided Test Product, body cleanser, and sunscreen for the duration of the study (14 weeks). • Be willing to NOT undergo ANY cosmetic procedures on the upper arms & knees for the duration of the study (14 weeks). • Be available to visit the office 5 times during the study period (14 weeks). • Be willing to have photographs taken of your upper arms & knees, and sign a photography release authorizing Alastin Skincare, Inc. to use and/or publish your photographs for promotional purposes. • Be willing to maintain a consistent body weight for the duration of the study. Individuals currently undergoing weight loss treatments can be considered for study participation, provided the dose is stable and a consistent body weight is maintained for the duration of the study (14 weeks). • Meet additional study qualification criteria. Eligible individuals that meet all study qualification criteria and complete ALL study visits will be compensated for their time and travel in the amount of $250 ($50 per study visit) and offered to choose any three (3) Alastin commercially available products, which can be valued at a retail cost up to $700. STUDY LOCATION & CONTACT: Galderma; Alastin Skincare, Inc. 5999 Avenida Encinas, Ste 100, Carlsbad, CA 92008 Lora Colvan, R&D Advisor

Suffering from Asthma? Asthma is a chronic respiratory condition characterized by inflammation and narrowing of the airways, making it difficult to breathe. This occurs when the bronchial tubes, which carry air to the lungs, become swollen and constricted, often accompanied by increased mucus production. Common symptoms include wheezing, coughing, shortness of breath, and chest tightness. These symptoms can vary in severity and frequency, ranging from mild and occasional to severe and life-threatening. Asthma attacks can be triggered by various factors, including allergens, irritants, respiratory infections, exercise, and cold air. We are currently recruiting patient volunteers with asthma to participate in a clinical trial evaluating a new investigational medication designed to improve symptom control and lung function. Your participation could contribute to the development of a potentially more effective treatment for asthma. If you or someone you know may be interested, please contact us to learn more about eligibility and potential benefits. Our Clinical Trials is launching a new research study for individuals with Asthma and is in search of qualified participants! We need patient volunteers to help test the effectiveness of a new medication for this condition. The medication will be provided at no cost to you or your insurance. Participants will receive compensation for their time and travel. Plus, refer a qualifying friend and earn a bonus of $100! Call 828-579-2273 Now! Or Apply Here Why Participate? ●Compensation: Get compensated up to $100 per clinic visit with no cost to you or your insurance! ●Comprehensive Support: Regular check-ins and assessments to ensure your health is a priority. Our trial is conducted by experienced healthcare professionals dedicated to your well-being. ●Free study medications: Study medication for Asthma is given at no cost! To qualify: ●18-75 years of age ●Clinical Diagnosis of Asthma for 12 months ●On stable, non-biologic, background asthma medication Check out our other studies! * Thyroid Eye Disease * Stage 3 Type 1 Diabetes * Chronic Low Back Pain * Future Studies Asheville Clinical Research Your participation can help advance Asthma research and improve lives. If you're ready to take action, contact us at 828-579-2273 or visit Asheville Clinical Research website for more information. Get Involved Today!

Suffering from Back Pain? Chronic low back pain is defined as pain in the lower back that persists for 12 weeks or more, often continuing even after the initial injury or cause has healed. It may originate from muscle or ligament strain, degenerative disc disease, spinal stenosis, or nerve irritation, but in many cases, the exact cause remains unclear (non-specific). Risk factors include poor posture, repetitive lifting, obesity, age-related changes, and a sedentary lifestyle. This condition can lead to reduced mobility, sleep disturbances, and emotional stress, significantly impacting an individual's daily functioning and overall quality of life. Effective management often involves a combination of physical therapy, medication, lifestyle modifications, and sometimes interventional procedures. We are seeking volunteers for a clinical study evaluating the safety and effectiveness of a treatment for Chronic low back pain. If you or someone you know may be interested, please contact us to learn more about eligibility and potential benefits. Our Clinical Trials is launching a new research study for individuals with Chronic Low Back Pain and is in search of qualified participants! We need patient volunteers to help test the effectiveness of a new medication for this condition. The medication will be provided at no cost to you or your insurance. Participants will receive compensation for their time and travel. Plus, refer a qualifying friend and earn a bonus of $100! Call 828-579-2273 Now! Or Apply Here Why Participate? Compensation: Get compensated up to $100 per clinic visit with no cost to you or your insurance! Comprehensive Support: Regular check-ins and assessments to ensure your health is a priority. Our trial is conducted by experienced healthcare professionals dedicated to your well-being. Free study medications: Study medication for Chronic Low Back Pain is given at no cost! To qualify: *Must be 18 years old and above *Suffering from low back pain Check out our other studies! * Thyroid Eye Disease * Future Studies Asheville Clinical Research Your participation can help advance Chronic Low Back Pain research and improve lives. If you're ready to take action, contact us at 828-579-2273 or visit Asheville Clinical Research website for more information. Get Involved Today!

Struggling with Stage 3Type 1 Diabetes? Take Part in Our Clinical Trial! Stage 3 Type 1 Diabetes is when the disease becomes active, and symptoms are noticeable. By this point, the immune system has destroyed most of the pancreas’s insulin-producing cells, causing high blood sugar. Symptoms often include frequent urination, extreme thirst, weight loss, fatigue, and blurry vision. Insulin therapy is required immediately to manage blood sugar and prevent serious health issues. We’re currently conducting a clinical study to explore potential new treatments for people living with this condition improving blood sugar control and enhancing overall well-being. Participants will receive study-related care, medication at no cost, and may be eligible for compensation. We are seeking volunteers for a clinical study to assess the safety and Stage 3Type 1 Diabetes. If you or someone you know may be interested, please contact us to learn more about eligibility and potential benefits. Plus, refer a friend who qualifies and earn a BONUS of $100! Call 828-579-2273 Now! Or Apply Here Why Participate? Compensation: Get compensated up to $100 per clinic visit with no cost to you or your insurance! Comprehensive Support: Regular check-ins and assessments to ensure your health is a priority. Our trial is conducted by experienced healthcare professionals dedicated to your well-being. Free study medications: Study medications for Stage 3 Type 1 Diabetes are given at no cost. To qualify: *1 - 25 years old *Diagnosed with Type 1 Diabetes Check out our other studies! * Moderate to Severe Plaque Psoriasis * Thyroid Eye Disease * Future Studies Asheville Clinical Research Your participation can help advance Type 2 Diabetes research and improve lives. If you're ready to take action, contact us at 828-579-2273 or visit Asheville Clinical Research website for more information. Get Involved Today!