Participant needed for a Research Study! What is the purpose of the study? The study will look at whether taking clozapine (Clozaril®) once a day is just as good as taking it twice a day by observing participants who are currently taking Clozapine twice daily. Participants will randomly be assigned to either the treatment as usual maintenance group (i.e, taking clozapine twice daily) or the switch group (i.e., taking clozapine once daily). Who is needed? • Individuals diagnosed schizophrenia/schizoaffective disorder, receiving clozapine twice daily for 3 months • Age range: 18+ • Gender: All • Ethnicity: All What does the study involve? • Number of contacts: 6 visits following a screening for eligibility • Time period: 12 weeks • Length of contacts: 1-hour visits • Treatment offered: No Study Location(s): 250 College St. 100 Stokes St. (Queen Site) Investigator(s): Dr. Gary Remington Contact Information: • Phone: 416-535-8501 ext. 34321 • E-mail: carol.borlido@camh.ca Study End Date: 01 January 2027 REB number: 096/2015 Full Study Title: Switching from Twice-Daily to Once-Daily Clozapine Dosing in Schizophrenia: A Pilot, Double-Blind, Randomized Controlled Trial The security of information sent by email cannot be guaranteed. Please do not communicate personal sensitive information by email. All information obtained during the study will remain strictly confidential. For more information about programs and services at CAMH please visit www.camh.ca or call 416-535-8501 (or 1-800-463-6273)