Dental Office Manager

Location:                     Boston, MA, or London, UK Reporting to:               Chief Medical Officer   Orchard Therapeutics, a Kyowa Kirin company, is a global gene therapy leader focused on transforming the life of patients with rare disorders through innovative gene therapies based on gene-modified hematopoietic stem cell (HSC). Orchard has its global headquarters in London and U.S. headquarters in Boston.   Reporting to the Chief Medical Officer, the VP of Clinical Development will oversee the activities of the Clinical Science organization.  This person will be key in driving the strategy for clinical development, the clinical development plans, managing the clinical studies, drive the regulatory documentations/presentations, writing and executing regulatory interactions together with the regulatory teams. This person will have oversight of Clinical Science across the Orchard portfolio and will serve as a key member of the Medical/Clinical Development (MCD) leadership team. Responsibilities   ·         Lead the Clinical Science team on execution of departmental objectives, and provide guidance on design of clinical development strategies and protocols that meet strategic, scientific and regulatory objectives of Orchard’s clinical assets ·         Cultivate a high-performing, collaborative culture through leadership of the Clinical Science leads to advance professional development for individual assets/franchises. Development department annual operating plan (AOP) and ensure adherence to annual budget targets, including effective oversight of third party vendors ·         Monitors departmental progress on program objectives and develops contingency plans as needed ·         Manage departmental activities pertaining to clinical development plans, study endpoint selection including laboratory endpoints, study execution, medical monitoring, safety monitoring, study report development/medical writing, etc. ·         Accountable for ensuring departmental adherence to GxP, particularly GCP, as well as all relevant Orchard policies and SOPs ·         Ensure effective cross-functional collaboration with Clinical Operations, Data Management, Biostatistics, Regulatory, Medical Affairs, Pharmacovigilance and other teams supporting clinical development ·         Actively contribute to the preparation of regulatory documents related to the area of work.  Represents Orchard Clinical Development in meetings with regulators (FDA, EMA, MHRA, etc.). ·         Assess signal detection, early safety signals with the PV team and represent Clinical Development on Safety Governance teams ·         Participates in planning/driving medical affairs activities together with the medical team. May represent the organization in congresses, patient advocacy groups, etc ·         Serve as clinical subject matter expert across the organisation. ·         Participates in business development initiatives for new programs ·         Able to work and navigate the complexities of academic/biotech interface, working as part of a global organisation, building and maintaining relationships with external stakeholders, and integrated working with academic partners. ·         Up to 20% travel required Requirements Experience   ·         At least 10 years experience in clinical development ·         Highly desirable experience – ultra rare disease, gene therapy, paediatrics, neurometabolic disease, IBD ·         Demonstrated experience in leading a matrix team, vendors and clinical development activities ·         Managerial experience ·         In depth understanding of regulatory environment, GCP/ICH, experience interacting with regulatory agencies ·         Proven track record of designing, leading, and executing clinical trials (Phases I–III). ·         Highly desirable experience – leadership of a regulatory file process (eg BLA, EU MAA, IND, CTA) ·         Experience working with complex programmes, ideally experience in Gene/Cell Therapy programs ·         Demonstrated ability to develop and execute clinical development strategies that align with broader corporate goals ·         Desired experience – pharmacovigilance reporting, management, and operations ·         Desired experience – US regulatory environment, US government affairs   Skills   ·         Proven leadership and decision-making skills – A mature professional capable of independently leading teams and making sound recommendations to senior management or board-level stakeholders. ·         Highly accountable and dependable – Takes ownership of responsibilities and consistently delivers results. ·         Collaborative and team-oriented – Works effectively across functions, building strong relationships, seeking critical insights, and constructively challenging assumptions to drive resource optimization. ·         Strong record of building and mentoring high-performing clinical teams. ·         Strategic thinker – Brings a forward-looking mindset to problem-solving, aligning actions with long-term goals. ·         Exceptional organizational skills – Able to manage multiple priorities and projects simultaneously, adapting to changing business needs. ·         Excellent presentation and communication skills – Proficient in delivering information and understanding through email and verbal forums, including using tools such as Excel and PowerPoint. ·         Flexible and solutions-driven – Brings a positive, “can-do” attitude and readily adapts to changing circumstances. ·         Experienced in remote collaboration – Able to work effectively within a virtual or distributed organization. ·         Experience overseeing global, multi-center trials, understanding regional regulatory and operational differences. ·         Strong data management capabilities – Skilled in handling and interpreting complex datasets to inform decisions. Experience with data monitoring committees and adjudication boards. ·         Thrives in dynamic ‘biotech’ environment – Performs effectively in high-stakes or fast-paced environments. ·         Influential collaborator – Able to engage and partner with world-leading experts to drive initiatives forward. Education   ·         Medical Degree (MD/MBBS) ·         Ideally background in gene therapy, immunology, and or haematology/oncology

 Essnova Solutions, Inc.  United States (Remote)  Job Title: Federal Contracts Manager (As-Needed Consultant Position)  Location: Remote  Employment Type: Part Time  Reports To: Director of Operations  Citizenship: U.S. Citizenship required  Experience Required: 10+ years minimum federal contracts management experience    THE OPPORTUNITY  Essnova Solutions, Inc., an Inc. 500 federal contractor and SBA 8(a)/HUBZone-certified small business, is seeking a highly seasoned On-Demand Contracts Manager to support our rapidly growing federal contracting operations as we pursue large GWACs and complex federal opportunities. This is an as-needed consulting role ideal for experienced professionals who can provide expert-level guidance when critical contracting needs arise.    With access to powerful contract vehicles including GSA OASIS+, Seaport NxG, FAA eFAST, GSA MAS, and 8(a) STARS III, and deep capabilities in IT, Cybersecurity, Healthcare, Geospatial, and Environmental services, we are actively pursuing large GWAC opportunities and need immediate access to senior contracting expertise. As our engagement increases, this role may expand based on business needs and performance.    MANDATORY APPLICATION PROCESS: All applicants must complete the survey questionnaire at the link below. Applications without the questionnaire will not be considered for the role.    QUESTIONNAIRE LINK: https://forms.office.com/r/1amDa2v8we    Please allow 15-20 minutes for the questionnaire; these questions will help assess the mutual alignment. Additional Materials can be emailed to info@essnova.com    THE ROLE  We require a highly experienced Contracts Manager to offer expert support for essential contracting tasks as needed. The ideal candidate should respond promptly when engaged and be adaptable to different lead times, from urgent, same-day requests to planned activities with several days' notice. Clear communication regarding availability and lead time requirements is crucial.    KEY RESPONSIBILITIES  Primary Focus Areas for GWAC and Large Contract Pursuits:  • Intent to Team (ITT) Agreements: Draft and negotiate Intent to Team agreements for GWAC pursuits  • Teaming Arrangements: Structure complex teaming agreements for various contract types  • Prime/Subcontractor Agreements: Draft comprehensive subcontractor agreements with flow-downs  • GWAC Proposal Support: Provide contractual expertise for OASIS+, Seaport NxG, and other GWACs  • RFP Analysis & Compliance: Conduct thorough RFP reviews and develop compliance matrices  • Service Contract Act Compliance: Ensure compliance with SCA and Davis-Bacon requirements  • NDAs and PIAs: Fast-track confidentiality agreements for teaming discussions    REQUIRED QUALIFICATIONS  • Minimum 10+ years of federal contracts management experience  • GWAC Experience: Must have experience with at least 2 major GWACs  • Current knowledge of FAR/DFARS regulations and recent updates  • Bachelor degree in Business Administration, Law, or related field  • Experience with multiple contract types: T&M, FFP, CPFF, CPAF, IDIQ  • Proven track record with Intent to Team agreements  • Experience managing contracts valued at 0M+  • Experience with both prime and subcontractor perspectives    WHAT HAPPENS NEXT:  ✓ Complete the mandatory questionnaire in full  ✓ Submit additional materials via email  ✓ Your application will be reviewed within 48-72 hours  ✓ If qualified, an Essnova recruiting team member will contact you  ✓ Selected candidates proceed to a brief virtual interview    Essnova Solutions, Inc. is an Equal Opportunity Employer. We celebrate diversity and are committed to building an inclusive workplace for all.    Requirements REQUIRED QUALIFICATIONS  • Minimum 10+ years of federal contracts management experience  • GWAC Experience: Must have experience with at least 2 major GWACs  • Current knowledge of FAR/DFARS regulations and recent updates  • Bachelor degree in Business Administration, Law, or related field  • Experience with multiple contract types: T&M, FFP, CPFF, CPAF, IDIQ  • Proven track record with Intent to Team agreements  • Experience managing contracts valued at 0M+  • Experience with both prime and subcontractor perspectives 

Primary Therapist Boca Recovery Center Website Location: On Site - Springfield, Massachusetts Department: Clinical Services Reports to: Clinical Director Salary: Competitive, based on licensure and experience About Boca Recovery Center Founded in 2016, Boca Recovery Center is a nationally recognized addiction treatment provider specializing in substance use disorders and co-occurring mental health conditions. With locations in Florida, New Jersey, Indiana, and Massachusetts, we deliver evidence-based clinical care in a supportive, structured environment. Our team is committed to providing trauma-informed, client-centered services that promote lasting recovery. Position Overview We are seeking a compassionate and experienced Primary Therapist to join our clinical team in Springfield, Massachusetts. This role is responsible for conducting assessments, providing evidence-based counseling, coordinating care, and supporting clients through every stage of treatment. The ideal candidate will bring a trauma-informed and culturally competent approach to working with individuals with substance use and co-occurring disorders. Key Responsibilities Assess the counseling needs of clients using evidence-based tools such as the ASI or other validated assessments. Diagnose substance use and co-occurring disorders using DSM-5 criteria. Determine appropriate level of care using ASAM criteria. Obtain and review clinical records relevant to the current treatment episode. Collaborate with clients to develop individualized, recovery-oriented treatment plans with measurable goals. Deliver individual and group substance abuse counseling services in accordance with treatment plans. Conduct periodic reviews using ASAM to determine the need for continued services or discharge. Revise treatment plans as needed to reflect client progress and new challenges. Develop comprehensive discharge and transfer plans to ensure continuity of care. Coordinate with referral sources, including mental health professionals, criminal justice agencies, schools, and employers. Participate as an active member of a multidisciplinary treatment team. Provide clinical consultation and care coordination across departments. Document all assessments, counseling sessions, referrals, and follow-up services in the clinical record with proper signatures and dates. Attend daily and weekly staffing meetings as scheduled. Recognize and respond appropriately to psychiatric crises, including suicidality and homicidality. Adhere to agency policies, procedures, and mandatory reporting requirements. Maintain a culturally sensitive and ethical approach to all client interactions. Address and respond to issues related to addiction, trauma, and dual diagnosis based on clinical expertise. Essential Skills & Attributes Strong clinical assessment and documentation skills. Ability to work collaboratively as part of a multidisciplinary team. High level of ethical conduct and understanding of confidentiality laws. Ability to manage crisis situations with professionalism and composure. Effective verbal and written communication. Cultural awareness and sensitivity in therapeutic interactions. Requirements Minimum of 2 years’ experience in chemical dependency and psychiatric settings preferred. Master’s degree from an accredited college or university in Psychology, Social Work, Counseling, or a health-related field. Active licensure in the State of Massachusetts preferred. Knowledge of Joint Commission standards preferred. CPR certification required. Benefits Boca Recovery Center offers a comprehensive benefits package, including: Health Insurance Retirement Plans Disability Coverage Paid Time Off Professional Development Opportunities Join Boca Recovery Center and contribute to a mission-driven team dedicated to transforming lives through evidence-based care and compassionate clinical services.

The Normal Brand is a fast-growing apparel brand that sells clothing and accessories online and in over 500 stores globally. We're hiring for our retail brick-and-mortar store in Des Moines. We want a hard working, personable, goal-oriented team members to join us for the holiday season. The store is an experience where a clean, enjoyable, and fun environment is of utmost importance. Responsibilities • “Our goal is to make peoples’ day better, sell clothes, and have FUN!” • Greet our guests with a smile, and a warm welcome • Get to know your customer to suggestive sell to their lifestyle • Replenish sales floor as needed • Maintain a clean store and merchandise to Normal standards • Embrace an environment that is respectful in communication • Promote a safe and clean environment for customers and staffWhat will make you stand out • 1+ years of retail experience • Fashion/apparel industry experience • Passion for making people happy • Proficiency with Shopify and Shopify POS • Strong Integrity • Excellent fashion sense • Self Awareness • Humble, Hungry, and Smart Requirements • Must be available to work Black Friday ( 11/28/25 ) weekend and leading into the holiday season through December • Eager to learn through feedback and solve problems in a fast-paced environment • Hard working, team player, and goal oriented • Team player • People person - approachable, friendly • Independent, Goal oriented, Data driven, Competitive, and positive energy • Ability to adapt quickly to new systems and processes • Takes ownership • Inventory integrity • Flexible availability, nights and weekends Benefits • Paid hourly and bi-weekly • Bonus opportunities • Employee Discount Job Type: Seasonal / Part-time Start date: October 1st, 2025 End date: Mid January, 2026

Zirtual has partnered with a Texas law firm to find the right 1099 remote probate paralegal for their office. Zirtual is a work-life balanced company that offers law firms practice area specific, experienced virtual paralegals. Our US-based paralegals strive to meet and exceed attorney-client needs and expectations.  Zirtual offers paralegals in every practice area and state, both transactional and litigation.  Our paralegals are vital members of Zirtual. The paralegal is the main point of contact with their assigned client(s) and will work independently with the law firms. The paralegal will receive support from their assigned Account Supervisor, who will assist the paralegal & law firm relationship with plan modifications, questions, feedback on quality, delegation and collaboration best practices, and more. The paralegal will provide a high-level professional service by working on tasks and projects as assigned by the client, and ensuring they are executed on time and to the highest level of quality. The paralegal is responsible for being the main point of contact for their assigned client(s), and being familiar with each clients’ needs and preferences.  The paralegal must have consistent and proactive communication with clients and the Account Supervisors. Paralegals are expected to be available for clients during business hours as agreed upon with each client, but around-the-clock availability is not expected. Paralegals ensure time is entered on a daily basis using a provided tool, respond to all communication within a mutually established response time expectation tailored to each client’s needs, maintain detailed and up-to-date client profiles, and follow Zirtual's best practices for success. POSITION SUMMARY Remote Texas business with a focus on probate. Part-time Dallas County, Texas experience preferred Responsibilities Court Filings & Probate Administration Client & Beneficiary Communication Drafting, filing, inventories & accountings Miscellaneous tasks as assigned Additional Assets: -Experience with software like WealthCounsel -Experience with case management systems like Clio Requirements Paralegal experience handling Dallas County Probate Matters preferred, but not required. Business hour availability Reliable home internet and computer Remote work experience preferred Benefits Compensated a 1099 independent contractor

City Wide Facility Solutions is the largest management company in the building maintenance industry, facilitating janitorial and more than 20 additional maintenance services for every client. But we do more than manage maintenance services for commercial facilities – we pride ourselves on being a partner that helps save time and solve problems! We are currently looking for Janitorial Independent Contractors to partner with to help fulfill the needs of our clients. City Wide can help your business grow, focus on the work, not on selling and collecting on the accounts, and most importantly, increase your income. If you are interested in joining the City Wide Network as an independent contractor - please apply to this posting. Requirements INDEPENDENT CONTRACTORS MUST PROVIDE THE FOLLOWING: Valid Business License, LLC or Inc. Worker's Compensation Insurance or Waiver General Liability Insurance Federal EIN #. Verifiable references. 18 years of age minimum. Favorable background investigation results. You can NOT be a sole proprietor. Benefits This is a contract position and not benefits eligible.